clozapine

noun

clo·​za·​pine ˈklō-zə-ˌpēn 

: an antipsychotic drug C₁₈H₁₉ClN₄ used in the treatment of schizophrenia

Examples of clozapine in a Sentence

Recent Examples on the Web

Medication side effects: Nonsteroidal anti-inflammatory drugs (NSAIDs) like Motrin (ibuprofen), serotonin receptor agonists like Clozaril (clozapine), and anticancer medications can all affect GI health. —Mark Gurarie, Health, 2 Nov. 2024

Currently, the drug clozapine is the only option for treatment-resistant schizophrenia. —Claire Bugos, Verywell Health, 30 Sep. 2024

The center is also participating in the clozapine study. —Angela Roberts, Baltimore Sun, 1 July 2024

Other countries have been more discerning about clozapine’s public health calculus, resulting in less-stringent monitoring regulations and more widespread clozapine prescribing. —Brian Barnett, STAT, 9 May 2022

To prevent and rapidly address cases of agranulocytosis, the FDA requires clozapine’s manufacturers to jointly administer the clozapine REMS program. —Brian Barnett, STAT, 9 May 2022

Frustratingly, the antipsychotic that works best against schizophrenia’s symptoms—clozapine, which emerged in the late 1980s—can have the nastiest unwanted effects, including weight gain, diabetes, and excessive sleepiness. —WIRED, 10 Feb. 2023

For them, clozapine is the gold standard treatment. —Brian Barnett, STAT, 9 May 2022

Many medications can cause excess salivation, such as clonozapam (Klonopin) and clozapine (Clozaril). —Dr. Keith Roach, oregonlive, 7 Oct. 2021

Word History

Etymology

International Scientific Vocabulary chlor- + -zapine, alteration of -azepine (as in benzodiazepine)

First Known Use

1970, in the meaning defined above

Medical Definition

clozapine

noun

clo·​za·​pine ˈklō-zə-ˌpēn 

: an antipsychotic drug C₁₈H₁₉ClN₄ with serious side effects (as seizures and agranulocytosis) that is used in the management of schizophrenia

Note: Clozapine is marketed under the trademark Clozaril.