cyclooxygenase

noun

cy·​clo·​ox·​y·​gen·​ase ˌsī-klō-ˈäk-si-jə-ˌnās 

: an enzyme that catalyzes the conversion of arachidonic acid to prostaglandins and that has two isoforms of which one is involved in the creation of prostaglandins which mediate inflammation and pain

Examples of cyclooxygenase in a Sentence

Recent Examples on the Web

The compound blocks numerous inflammatory markers, including cyclooxygenase (COX) enzymes, which play a role in pain and inflammation.26 Resveratrol may be beneficial in treating and preventing pain and discomfort caused by inflammatory conditions like arthritis. —Barbie Cervoni, Health, 23 Nov. 2024

Advil blocks the synthesis of prostaglandins and COX (cyclooxygenase) enzymes. —Femi Aremu, Verywell Health, 29 Oct. 2024

That’s because curcumin inhibits an enzyme called cyclooxygenase, or COX, which creates a chemical that coats the stomach to prevent acid from triggering ulcers. —Kristen Fischer, Health, 24 Sep. 2023

Word History

Etymology

cycl- + oxygenase, an enzyme, from oxygen + -ase

First Known Use

1974, in the meaning defined above

Medical Definition

cyclooxygenase

noun

cy·​clo·​ox·​y·​gen·​ase ˌsī-klō-ˈäk-si-jə-ˌnās  -äk-ˈsij-ə- 

-ˌnāz

: an enzyme that catalyzes the conversion of arachidonic acid to prostaglandins, that is inactivated by aspirin and other NSAIDs, and that has two isoforms of which one is involved in the cascade of events producing the pain and inflammation of arthritis and the other is not see cox-1, cox-2