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Though by definition these loss-of-function variants don't kill you, in general there is the assumption that this class of mutants does exhibit some fitness drag (e.g., the fitness of a heterozygote for a variant which is lethal as a homozygote genotype may be ~0.90).—Razib Khan, Discover Magazine, 22 Feb. 2012 The heterozygote combinations are for a variety of species, as indicated in the figure text.—Razib Khan, Discover Magazine, 27 July 2010 Observe that the heterozygote seems to exhibit a value closer to the European/light homozygote than the the African/dark homozygote!—Razib Khan, Discover Magazine, 25 July 2011 Sickle-cell disease one of the classical illustrations of heterozygote advantage, whereby those who carry one copy of the mutation on the gene have increased fitness vis-a-vis those who carry two normal copies of the gene.—Razib Khan, Discover Magazine, 22 July 2010 But consider a scenario where one parent is a heterozygote, and the other a homozygote for the dominant trait.—Razib Khan, Discover Magazine, 17 Aug. 2010
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