isotretinoin

noun

iso·​tret·​i·​noin ˌī-sō-ˈtre-tə-ˌnȯin 

: a cis isomer of retinoic acid that is a synthetic derivative of vitamin A, inhibits sebaceous gland function and keratinization, and is used in the treatment of severe inflammatory acne but is contraindicated in pregnancy because of its implication as a cause of birth defects

Examples of isotretinoin in a Sentence

Recent Examples on the Web

When taken orally, retinoids (like isotretinoin, aka Accutane) have been found to potentially cause birth defects or miscarriage. —Jasmine Browley, Allure, 13 Dec. 2024

According to multiple clinical studies, between 85 to 98 percent of patients reported that isotretinoin improved their acne or were free of acne. —Emma Sandler, Allure, 26 Nov. 2024

Oral isotretinoin: This is a prescription oral retinoid that can help shrink oil glands that cause Fordyce spots. —Carley Millhone, Health, 19 Oct. 2024

And of course, there’s the closest cure-all for acne, isotretinoin (once sold under the name Accutane), which has a 85% success rate but comes with side effects that—for some people, particularly women—can come at the cost of your mental health and physical well-being. —Ariana Yaptangco, Glamour, 14 Oct. 2024

Word History

First Known Use

1979, in the meaning defined above

Medical Definition

isotretinoin

noun

iso·​tret·​i·​noin ˌī-sō-ˈtret-ə-ˌnȯin 

: a cis isomer of retinoic acid that is a synthetic derivative of vitamin A, that inhibits sebaceous gland function and keratinization, and that is administered in the treatment of severe inflammatory acne but is contraindicated in pregnancy because of its implication as a cause of birth defects

called also 13-cis-retinoic acid, retinoic acid

see accutane