sclerostin

noun

scle·​ros·​tin sklə-ˈräs-tən 

: a glycoprotein produced in osteocytes that inhibits bone formation by suppressing osteoblast differentiation and in a mutated form results in excess bone formation

Romosozumab is a monoclonal antibody directed against sclerostin, a glycoprotein that prevents mesenchymal cells from becoming osteoblasts. By inhibiting sclerostin, romosozumab promotes osteoblast production.

—Bruce Jancin, Frontier Medical News

Sclerostin has been identified as an important regulator of bone homeostasis … and it is involved in the pathogenesis of many different skeletal diseases.

—Elias S. Vasiliadis et al., Journal of Clinical Medicine

Humans with genetic deficiencies of sclerostin … have high bone mass, increased bone strength, and resistance to fracture.

—Carolyn B. Becker, The New England Journal of Medicine