tolerance

noun

tol·​er·​ance ˈtä-lə-rən(t)s 

ˈtäl-rən(t)s

1

: capacity to endure pain or hardship : endurance, fortitude, stamina

2

a

: sympathy or indulgence for beliefs or practices differing from or conflicting with one's own

b

: the act of allowing something : toleration

3

: the allowable deviation from a standard

especially : the range of variation permitted in maintaining a specified dimension in machining a piece

4

a(1)

: the capacity of the body to endure or become less responsive to a substance (such as a drug) or a physiological insult especially with repeated use or exposure

developed a tolerance to painkillers

also : the immunological state marked by unresponsiveness to a specific antigen

(2)

: relative capacity of an organism to grow or thrive when subjected to an unfavorable environmental factor

b

: the maximum amount of a pesticide residue that may lawfully remain on or in food

Synonyms

• forbearance
• long-suffering
• patience
• sufferance

Examples of tolerance in a Sentence

a tolerance for other lifestyles

The plants have a high tolerance for heat.

Some patients gradually develop a tolerance for the drug and need to be given a larger dose.

Some patients develop greater tolerance for the drug's effects.

Recent Examples on the Web

Getty Images When saving for retirement, more time in the market can be beneficial depending on your goals and risk tolerance. —Kate Dore, Cfp®, Ea, CNBC, 10 Feb. 2025

Reporting Highlights Court Fight: During internal meetings, a political appointee said Trump could not have a higher tolerance for legal risk. —Anna Maria Barry-Jester, ProPublica, 9 Feb. 2025

Established plants have some drought tolerance, and grow at a similar pace overall to flowering dogwood. —Miri Talabac, Baltimore Sun, 7 Feb. 2025

The fund was created with Brin’s high tolerance for risk in mind, which sets him apart from other philanthropists and venture capital investors, according to renowned biochemist Robert Tjian, a professor at UC Berkeley who’s also an advisor at The Column Group and helped seed the idea for the fund. —Phoebe Liu, Forbes, 6 Feb. 2025

Word History

First Known Use

15th century, in the meaning defined at sense 1

Phrases Containing tolerance

• cross-tolerance
• self-tolerance
• zero tolerance

Kids Definition

tolerance

noun

tol·​er·​ance ˈtäl(-ə)-rən(t)s 

1

a

: ability to put up with something harmful or unpleasant

b

: the ability to adjust to a food or drug so that its effects are experienced less strongly

2

: sympathy for or acceptance of feelings, habits, or beliefs that are different from one's own

Medical Definition

tolerance

noun

tol·​er·​ance ˈtäl(-ə)-rən(t)s 

1

: the capacity of the body to endure or become less responsive to a substance (as a drug) or a physiological insult especially with repeated use or exposure

developed a tolerance to painkillers

2

: the immunological state marked by unresponsiveness to a specific antigen