7-hydroxymitragynine

noun

7-hy·​droxy·​mi·​trag·​y·​nine ˈse-vən-hī-ˌdräk-sē-mi-ˈtra-jə-ˌnēn 

: a psychoactive indole alkaloid C₂₃H₃₀N₂O₅ that is a potent oxidized derivative of mitragynine present in kratom

Mitragynine is the more prominent and has very mild opioid effects, while 7-hydroxymitragynine is 13 times more potent than morphine milligram for milligram.

—C. Michael White

[Mac] Haddow, the lobbyist, blamed kratom deaths on "bad actors" who run the leaf through a chemical process during production to dangerously increase natural levels of 7-hydroxymitragynine in the plant, which, he agreed, can cause fatal overdoses similar to opioids.

—Jesse Bogan

Examples of 7-hydroxymitragynine in a Sentence

Recent Examples on the Web

Its two primary alkaloids — mitragynine and 7-hydroxymitragynine — activate the mu-opioid receptors in the brain. —Helen Freund and Kirby Wilson, Sun Sentinel, 6 Mar. 2023

Word History

Etymology

hydroxy + mitragynine

First Known Use

2004, in the meaning defined above

Medical Definition

7-hydroxymitragynine

noun

7-hy·​droxy·​mi·​trag·​y·​nine ˈsev-ən-hī-ˌdräk-sē-mi-ˈtraj-ə-ˌnēn 

: a psychoactive indole alkaloid C₂₃H₃₀N₂O₅ that is a potent oxidized derivative of mitragynine present in kratom

… 7-hydroxymitragynine exhibits 40-fold greater potency than mitragynine and tenfold greater potency than morphine, whereas mitragynine is less potent than morphine …

—D. A. Todd et al., Scientific Reports