depletion

noun

de·​ple·​tion di-ˈplē-shən 

: the act or process of depleting or the state of being depleted: as

a

: the reduction or loss of blood, body fluids, chemical constituents, or stored materials from the body (as by hemorrhage or malnutrition)

b

: a debilitated state caused by excessive loss of body fluids or other constituents