endogenous

adjective

en·​dog·​e·​nous en-ˈdä-jə-nəs How to pronounce endogenous (audio)
1
: growing or produced by growth from deep tissue
endogenous plant roots
2
a
: caused by factors inside the organism or system
suffered from endogenous depression
endogenous business cycles
b
: produced or synthesized within the organism or system
an endogenous hormone
endogenously adverb

Did you know?

When biologists need to make a distinction between things that are produced within a cell or organ and things that affect it from the outside, they use the terms endogenous and exogenous. It used to be thought, for instance, that mutations in cells always resulted from exogenous causes, until it was discovered that substances in the body, including those called oxidants, could cause them endogenously as well. "Circadian rhythms"—the regular cycles, roughly 24 hours in length, that plants, animals, and humans rely on to regulate their days—are endogenously generated and don't actually depend on the sun for their timing.

Examples of endogenous in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
It’s derived from a fern from South America, and contains an endogenous photo protective factor. Megan McIntyre, Allure, 26 Feb. 2025 Scientists think that the endogenous opioid system evolved, in part, to push animals toward behaviors that aided the species’ survival. Moises Velasquez-Manoff Robert Petkoff Emma Kehlbeck Zak Mouton, New York Times, 16 Feb. 2025 Endorphins, released during exercise, are one type of endogenous opioid. Moises Velasquez-Manoff Robert Petkoff Emma Kehlbeck Zak Mouton, New York Times, 16 Feb. 2025 Following the discovery of endogenous creatine synthesis in the human brain, research quickly moved to understand what role this compound plays in things like cognition and mood. Rich Haridy, New Atlas, 29 Jan. 2025 See All Example Sentences for endogenous

Word History

First Known Use

1830, in the meaning defined at sense 1

Time Traveler
The first known use of endogenous was in 1830

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Cite this Entry

“Endogenous.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/endogenous. Accessed 10 Mar. 2025.

Medical Definition

endogenous

adjective
en·​dog·​e·​nous en-ˈdäj-ə-nəs How to pronounce endogenous (audio)
variants also endogenic
1
: growing from or on the inside
endogenous spores
2
: caused by factors within the body or mind or arising from internal structural or functional causes
endogenous malnutrition
endogenous psychic depression
3
: relating to or produced by metabolic synthesis in the body
endogenous opioids
endogenous amino acids
compare exogenous
endogenously adverb
Last Updated: - Updated example sentences
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