gangliosidosis

noun

gan·​gli·​o·​si·​do·​sis ˌgaŋ-glē-ˌō-sī-ˈdō-səs 

plural gangliosidoses -ˌsēz 

: any of several inherited metabolic diseases (as Tay-Sachs disease) characterized by an enzyme deficiency which causes accumulation of gangliosides in the tissues