malignant

adjective

ma·​lig·​nant mə-ˈlig-nənt 

1

: tending to produce death or deterioration

malignant malaria

especially : tending to infiltrate, metastasize, and terminate fatally

a malignant tumor

2

a

: evil in nature, influence, or effect : injurious

a powerful and malignant influence

b

: passionately and relentlessly malevolent : aggressively malicious

the malignant tongues of gossipers

c

obsolete : malcontent, disaffected

malignantly adverb

Synonyms

• bad [slang]
• bitchy
• catty
• cruel
• despiteful
• hateful
• malevolent
• malicious
• malign
• mean
• nasty
• spiteful
• vicious
• virulent

Examples of malignant in a Sentence

a highly malignant form of cancer

a powerful and malignant influence

Recent Examples on the Web

Mia Love, the first Black Republican woman elected to Congress, is no longer responding to treatment for an aggressive and malignant brain tumor known as glioblastoma, with which she was diagnosed in 2022. —Cara Lynn Shultz, People.com, 3 Mar. 2025

Small cell lung cancer (SCLC) is a highly malignant and very aggressive type of cancer responsible for about 13% of all lung cancers. —Michael Franco, New Atlas, 13 Feb. 2025

Advocates in both parties have long championed USAID as a cost-effective way to build alliances globally and counter the malignant influence of rivals like Russia and especially ascendant China. —Dave Goldiner, New York Daily News, 7 Feb. 2025

Eyelid tumors in cats are not very common and almost always malignant. —Dr. John De Jong, Boston Herald, 16 Feb. 2025

Word History

Etymology

Late Latin malignant-, malignans, present participle of malignari

First Known Use

1542, in the meaning defined at sense 2c

Phrases Containing malignant

• malignant melanoma

Rhymes for malignant

• indignant
• nonmalignant
• premalignant

Kids Definition

malignant

adjective

ma·​lig·​nant mə-ˈlig-nənt 

1

: evil in influence or effect : injurious

2

: malicious sense 1

3

: tending to produce death

malignant tumors

malignantly adverb

Medical Definition

malignant

adjective

ma·​lig·​nant mə-ˈlig-nənt 

1

: tending to produce death or deterioration

malignant malaria

especially : tending to infiltrate, metastasize, and terminate fatally

malignant tumors

compare benign sense 1

2

: of unfavorable prognosis : not responding favorably to treatment

psychotic reactions with a malignant trend