methotrexate

noun

meth·​o·​trex·​ate ˌme-thə-ˈtrek-ˌsāt How to pronounce methotrexate (audio)
: a toxic folic acid analog C20H22N8O5 that is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

Examples of methotrexate in a Sentence

Recent Examples on the Web
These examples are automatically compiled from online sources to illustrate current usage. Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.
The most widely used of them is injectable methotrexate sodium, a chemotherapeutic often used for acute lymphoblastic leukemia, brain tumors, non-Hodgkin lymphoma and osteosarcoma, according to St. Jude Children’s Research Hospital. Adrianna Rodriguez, USA TODAY, 17 Oct. 2024 Taking quercetin along with methotrexate, a common medication for treating rheumatoid arthritis, may improve the anti-inflammatory effects of the medication while reducing its toxic effects. Kelsey Kunik, Rd, Health, 10 Aug. 2024 Treatment Prevents Progression Traditional disease-modifying anti-rheumatic drugs (DMARDs), especially methotrexate, and biologics are considered the best options for slowing down disease progression. Lana Barhum, Verywell Health, 5 June 2024 In the 1950s, for instance, researchers linked a drug named methotrexate to an antibody that targets carcinoembryonic antigen, a common tumor marker, and tested whether the construct could treat advanced colorectal and ovarian cancers in people. Jyoti Madhusoodanan, Scientific American, 1 Mar. 2024 See all Example Sentences for methotrexate 

Word History

Etymology

meth- + -trexate, of unknown origin

First Known Use

1955, in the meaning defined above

Time Traveler
The first known use of methotrexate was in 1955

Dictionary Entries Near methotrexate

Cite this Entry

“Methotrexate.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/methotrexate. Accessed 16 Nov. 2024.

Medical Definition

methotrexate

noun
meth·​o·​trex·​ate ˌmeth-ə-ˈtrek-ˌsāt How to pronounce methotrexate (audio)
: a toxic drug C20H22N8O5 that is an analog of folic acid and is used to treat certain cancers, severe psoriasis, and rheumatoid arthritis

called also amethopterin

More from Merriam-Webster on methotrexate

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!