neurofibromatosis

noun

neu·​ro·​fi·​bro·​ma·​to·​sis ˌnu̇r-ō-(ˌ)fī-ˌbrō-mə-ˈtō-səs 

ˌnyu̇r-

: a disorder inherited as an autosomal dominant and characterized especially by brown spots on the skin, neurofibromas of peripheral nerves, and deformities of subcutaneous tissue and bone

Examples of neurofibromatosis in a Sentence

Recent Examples on the Web

Appearance and Sensations Each type of neurofibromatosis has specific patterns of symptoms. —Brigid Dwyer, Verywell Health, 20 July 2024

But his best role came in this dark comedy about identity, playing an actor with disfiguring neurofibromatosis. —Brian Truitt, USA TODAY, 12 Dec. 2024

Stan spends the first half of A Different Man under a significant amount of prosthetic makeup as a man with neurofibromatosis. —Joe Reid, Vulture, 10 Dec. 2024

In Aaron Schimberg’s A Different Man, Sebastian Stan stars as Edward Lemuel, a struggling actor with low self-esteem who undergoes a medical procedure to cure him of a condition called neurofibromatosis that has caused his face to be disfigured. —Brande Victorian, The Hollywood Reporter, 2 Dec. 2024

Word History

Etymology

neurofibromat-, Greco-Latin stem of neurofibroma + -osis

First Known Use

1896, in the meaning defined above

Medical Definition

neurofibromatosis

noun

neu·​ro·​fi·​bro·​ma·​to·​sis -fī-ˌbrō-mə-ˈtō-səs 

plural neurofibromatoses -ˌsēz 

1

also neurofibromatosis type 1 or neurofibromatosis 1 : an inherited developmental disorder characterized especially by brown spots on the skin that are typically present at birth, neurofibromas of peripheral nerves, and deformities of subcutaneous tissues and bone

—abbreviation NF, NF-1

called also Recklinghausen's disease, von Recklinghausen's disease

2

also neurofibromatosis type 2 or neurofibromatosis 2 : an inherited disorder characterized by bilateral acoustic neuromas developing in childhood or early adulthood that are typically accompanied by other nonmalignant tumors of the central nervous system

—abbreviation NF, NF-2

Note: Both types of neurofibromatosis are inherited as an autosomal dominant trait requiring that one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. Type 1 is much more common than type 2.