How to Use p53 in a Sentence

p53

noun

• The best known is the gene for a protein called p53, which stops cells from reproducing if their DNA is damaged.
  — The Economist, 16 Sep. 2017
• The reason why that could be a problem is that p53 dysfunction can cause cancer.
  — Sharon Begley, STAT, 11 June 2018
• Yet extra copies of p53 are not the elephants’ only source of protection.
  — Quanta Magazine, 7 Nov. 2017
• For example, naked mole rat cells amass large amounts of a protein called p53, which is known to suppress tumors.
  — Max G. Levy, Wired, 24 May 2021
• One key to making this work, said Suhr, is finding a way to compromise the function of a specific gene called p53.
  — Lindsey Botts, The Arizona Republic, 25 Apr. 2022
• This form of cancer is one where there doesn't seem to be a somatic cell mutation of p53 itself.
  — Razib Khan, Discover Magazine, 17 Oct. 2013
• Although p53 mutations greatly increase the risk of cancer, the findings are a reason to be cautious and not for full-blown alarm.
  — Fox News, 13 June 2018
• First, the fact that elephants possess multiple copies lowers the chance of p53 no longer working because of mutations.
  — Rachel Nuwer, Scientific American, 8 Sep. 2022
• But the same mutation seemed to have the opposite effect in the small intestine: mutant p53 actually prevented tumors from growing.
  — Hannah Seo, Popular Science, 20 Aug. 2020
• The scientists virtually modeled and examined elephants' 40 p53 proteins, finding two ways the gene could help elephants avoid cancer.
  — Rachel Nuwer, Scientific American, 8 Sep. 2022
• Vousden unexpectedly veered into that line of research while studying a cancer-preventing gene called p53.
  — Jocelyn Kaiser, Science | AAAS, 1 Apr. 2021
• Zwaka’s group made mouse embryonic stem cells (ESCs) with a supercompetitor mutation that lowered expression of p53, an important quality-control protein that normally puts the brakes on cell division.
  — Kendall Powell, Scientific American, 22 Jan. 2020
• However, inhibition of p53 leaves the cell transiently vulnerable to the introduction of chromosomal rearrangements and other tumorigenic mutations.
  — Sharon Begley, STAT, 19 June 2018

Last Updated: 15 Sep 2024