How to Use protease in a Sentence

protease

noun

• The drugs work by blocking a critical enzyme, a protease, that the virus needs to replicate.
  — Andrew Stuttaford, National Review, 24 Mar. 2021
• Hilgenfeld thought that molecule—called a protease—could hold the key.
  — National Geographic, 28 Apr. 2020
• Malone had his eyes on a viral enzyme called the papainlike protease, which helps the pathogen replicate.
  — Brendan Borrell, Science | AAAS, 26 Apr. 2020
• If a drug could prevent the main protease enzyme from working, the virus might stop replicating in cells and in turn, stop spreading throughout the body.
  — Dallas News, 1 July 2020
• Their design is a motor that follows a trail of peptide molecules laid down on a surface for the trypsin protease to bind to.
  — The Physics Arxiv Blog, Discover Magazine, 23 Sep. 2021
• Paxlovid is a made up of two protease inhibitors, including one used in treating HIV as a booster medicine.
  — Patrick Jackson, The Conversation, 28 Apr. 2022
• Paxlovid, known by its brand name, stops the virus by blocking an enzyme—called protease—involved in replication.
  — Felicia Schwartz, WSJ, 22 Jan. 2022
• The main protease enzyme breaks that long string of Legos into usable pieces, said Dr. Cisneros.
  — Dallas News, 1 July 2020
• Here are some tips: opt for a detergent that boasts enzymes, like protease, amylase, and lipase.
  — Amber Smith, Discover Magazine, 11 Apr. 2023
• That window is rather narrow for all polymerase and protease inhibitors.
  — William A. Haseltine, Scientific American, 1 Oct. 2020
• The drug Lopinavir is an inhibitor of an enzyme called HIV protease which is involved in the production of viral particles.
  — William Petri, The Conversation, 1 July 2020
• That’s one reason that, from the start, the team planned to combine their medicine with ritonavir, which is commonly used with protease inhibitors to treat HIV to increase blood levels of drug.
  — Matthew Herper, STAT, 28 Apr. 2022
• That team showed that an inhibitor of this protease blocked coronavirus infections in cultured cells.
  — John Timmer, Ars Technica, 20 Mar. 2020
• But the proteins are first built as long strings called polypeptides; an enzyme called protease then slices them into the fragments from which proteins are assembled.
  — Dhruv Khullar, The New Yorker, 21 Nov. 2021
• The drugs, called protease inhibitors, block the replication of the AIDS-causing virus by chemically binding a key enzyme.
  — Merrie Monteagudo, San Diego Union-Tribune, 15 Mar. 2022
• The combination of drugs, known by the brand name Kaletra, appears to work to stop enzymes called proteases from allowing the virus to mature and replicate.
  — Scientific American, 13 Feb. 2020
• The host cell proteases themselves also make a tempting target.
  — John Timmer, Ars Technica, 20 Mar. 2020
• A couple of months ago a group of scientists announced their discovery of a new drug candidate that inhibits that protease.
  — William A. Haseltine, Scientific American, 6 July 2020
• The protease inhibitors and other compounds look promising in cell and animal studies.
  — Science News Staff, Science | AAAS, 31 Dec. 2020
• In one lab study, Pfizer researchers tested nirmatrelvir against an enzyme called protease that the virus needs to generate copies of itself.
  — Jared S. Hopkins, WSJ, 18 Jan. 2022
• Researchers designed the pill to stop the coronavirus from spreading in people by blocking activity of a key enzyme, known as protease, which the virus needs to replicate.
  — Joseph Walker, WSJ, 22 Dec. 2021
• Its effectiveness is due to protease inhibitors in the drug that bind to viral enzymes, preventing viruses from replicating in the cell.
  — Tommy Beer, Forbes, 27 Apr. 2021
• This processing is needed before the virus is able to copy its own genome, so inhibiting the protease should block viral reproduction.
  — John Timmer, Ars Technica, 15 Dec. 2021
• Enanta’s drug, called EDP-235, targets the coronavirus protease without the need for ritonavir.
  — Ryan Cross, BostonGlobe.com, 9 Nov. 2022
• The Pfizer compound was developed to inhibit an enzyme called a protease.
  — William A. Haseltine, Forbes, 5 Apr. 2021
• Pfizer’s drug is part of a decades-old family of antiviral pills known as protease inhibitors, a standard treatment for HIV and hepatitis C.
  — Matthew Perrone, Anchorage Daily News, 1 Dec. 2021
• But the Pfizer drug is meant to work by inhibiting the virus’s ability to break into smaller pieces and replicate itself by dulling an enzyme called protease—not by battling spike proteins.
  — Colleen Stinchcombe, SELF, 14 Dec. 2021
• Another scientific breakthrough came in 1996, when the FDA approved the first protease inhibitors.
  — Harmeet Kaur, CNN, 5 June 2021
• Now, in a study of mice and human samples, a team of scientists has found that S. aureus releases an enzyme called V8 protease onto the skin, which helps activate itch-driving neurons.
  — Margaret Osborne, Smithsonian Magazine, 4 Dec. 2023
• The drug works differently from vaccines and monoclonal antibody treatments by targeting a different part of the virus, called proteases.
  — Kaitlin Sullivan, Health, 29 Sep. 2023

Last Updated: 21 Sep 2024