1
as in tying
to confine or restrain with or as if with chains
wanted to take the trip, but was handcuffed by her responsibility to watch her ailing father
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2
as in impeding
to create difficulty for the work or activity of
the fear that the new mandatory, standardized tests will handcuff the state's teachers, who will have to specifically tailor their lesson plans for the test
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Merriam-Webster unabridged
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