1
as in tired
depleted in strength, energy, or freshness
felt wiped out for several weeks after getting the flu
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2
as in drunk
slang
being under the influence of alcohol
thought that it'd be nice to attend a fraternity party in which everyone wasn't wiped out
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3
as in ripped
slang
being under the influence of a recreational drug
most of the club patrons were too wiped out to know or care what was happening
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as in eradicated
to destroy all traces of
he didn't get his gambling under control until he had already wiped out his entire life savings
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Merriam-Webster unabridged
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