1
as in to exploit
to control or take advantage of by artful, unfair, or insidious means
the con man would slyly manipulate the emotions of his marks in order to win their sympathy and trust
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2
as in to manage
to deal with (something) usually skillfully or efficiently
spin doctors manipulating the data to make it seem more favorable to their preferred candidates
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3
as in to negotiate
to plan out usually with subtle skill or care
manipulated the schedule of presidential primaries so that the choice of the party elders would win the nomination
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Merriam-Webster unabridged
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